Zyphra Inference Wave 2: Accelerating MoE and Long-Context Inference Serving on MI355X
Zyphra has released ZOE, its second-generation inference optimization, which on AMD Instinct MI355X reduces GLM-5.3's time to first token (TTFT) at 512K context from 178.8 seconds to 64.6 seconds (2.8x), and from 42.3 seconds to 11.8 seconds (3.6x) at 90% prefix cache hit rate. Its CSA top-K selection HIP kernel raises DeepSeek-V4-Pro's single-user decode throughput at 1M context from 43.5 to 61.1 tokens/s (1.40x). AMD MXFP4 quantization of GLM-5.3 shrinks the model from 756 GB to 410 GB, with benchmark scores such as AIME25 within 3 points of FP8.

Zyphra has released ZOE, its second-generation inference optimization, which on AMD Instinct MI355X reduces GLM-5.3's time to first token (TTFT) at 512K context from 178.8 seconds to 64.6 seconds (2.8x), and from 42.3 seconds to 11.8 seconds (3.6x) at 90% prefix cache hit rate. Its CSA top-K selection HIP kernel raises DeepSeek-V4-Pro's single-user decode throughput at 1M context from 43.5 to 61.1 tokens/s (1.40x). AMD MXFP4 quantization of GLM-5.3 shrinks the model from 756 GB to 410 GB, with b
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