OpenAI and others use 1,946 agents to interpret a mouse whole-brain CRISPR atlas in 32 minutes
OpenAI, PerturbAI, and Scripps Research used 1,946 GPT-Rosalind-5.5 agents to complete interpretation of a mouse whole-brain CRISPR atlas in 32 minutes; OpenAI estimates that manual work would take months. Each agent analyzed only the effect of a single gene knockout and retrieved literature, and did not access the atlas paper published after the model's December 2025 knowledge cutoff, yet still matched or refined 48 of 55 published findings supportable by the expression data. The core of the method is to split one giant analysis into nearly 2,000 single-gene small tasks executed in parallel; a single agent processing 893 genes cited only 11 papers, while after splitting the citation count was 711 times that, and blinded PhD reviewers preferred the split reports in 75% of cases.
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The original text provides a quantitative comparison of splitting one large-scale analysis into nearly 2,000 agents executed in parallel; the method itself can be transferred to other ultra-large-scale data interpretation.
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View original postGPT-Rosalind surfaced a new lead for drug discovery: could restoring cholesterol transport protect neurons from degeneration? DCTN1 is a gene linked to Perry syndrome, a rare neurodegenerative disorder. In mouse-brain data, disrupting it increased expression of genes involved in making cholesterol. GPT-Rosalind suggested a possible explanation: cholesterol may not be reaching where neurons need it. That gives scientists a specific mechanism to test and, if confirmed, a direction for developing new treatments for neurodegenerative disorders. With @perturbai_tx and @scrippsresearch, a team of thousands of GPT-Rosalind agents worked in parallel, connecting gene-expression results from millions of mouse brain cells with scientific literature in just 32 minutes. We’re now expanding this collaboration to identify new drug targets. https://t.co/oHdF3ELsMj
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GPT-Rosalind surfaced a new lead for drug discovery: could restoring cholesterol transport protect neurons from degeneration? DCTN1 is a gene linked to Perry syndrome, a rare neurodegenerative disorder. In mouse-brain data, disrupting it increased expression of genes involved in making cholesterol. GPT-Rosalind suggested a possible explanation: cholesterol may not be reaching where neurons need it. That gives scientists a specific mechanism to test and, if confirmed, a direction for developing new treatments for neurodegenerative disorders. With @perturbai_tx and @scrippsresearch, a team of thousands of GPT-Rosalind agents worked in parallel, connecting gene-expression results from millions of mouse brain cells with scientific literature in just 32 minutes. We’re now expanding this collaboration to identify new drug targets. https://t.co/oHdF3ELsMj
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