Understand this story
Leash Bio has released the Minos preprint, blog, and open dataset. In an interview published by Latent Space on October 15, 2026, co-founder Ian Quigley described the company's work on extracting clean, reproducible protein–small molecule interaction data from DNA-encoded libraries (DEL), and mentioned that the team is turning years of accumulated data into tens of thousands of lab-in-the-loop simulations for agents to perform verifiable scientific reasoning; this work later developed into Minos and led to the release of the preprint, blog, and open dataset. The interview also mentioned that in its Kaggle competition, none of the roughly 2,000 teams exceeded random performance on unseen chemical libraries, and that Hermes, using only its own data, matched Boltz on public benchmarks. The latest state that can currently be confirmed is the aforementioned release.
AI-generated from public reports
Latest development · Report
Leash Bio's Ian Quigley on DEL data, model cheating, and an agentic chemistry reasoning sandboxDevelopments
1 confirmed developments
- Source:Latent Space
Reports and discussion timeline
Browse reports and discussion by time. Their evidence levels remain distinct.
Oct 15
Latent Space
Leash Bio's Ian Quigley on DEL data, model cheating, and an agentic chemistry reasoning sandbox
In a Latent Space podcast interview, Leash Bio co-founder Ian Quigley discusses how the company tamed DNA-encoded libraries (DEL) and extracted clean, reproducible protein-small molecule interaction data from them. The interview mentions that in its Kaggle competition, none of the roughly 2,000 teams surpassed random performance on an unseen chemical library, and that a model can guess a chemist's identity from molecular structure, while Hermes, using only its own data, matched Boltz on public benchmarks. Ian also previewed that the team is turning years of accumulated data into tens of thousands of lab-in-the-loop simulations for agents to perform verifiable scientific reasoning; that work later developed into Minos, with a preprint, blog post, and open dataset released.