MoleculeMind MMDesign Technical Report: 18 of 19 Projects Succeeded, All 6 GPCR Targets Hit
MoleculeMind has released a technical report on its AI de novo protein design platform MMDesign, covering 19 design projects across 18 targets and two modalities—nanobodies and macrocyclic peptides—of which 18 yielded bindable molecules, for a project success rate of 94.7%; among 453 tested candidates, 139 were confirmed to bind, for a candidate hit rate of 30.7%. For all six GPCR targets CCR7, CCR8, EP2, GPR68, NK3R, and A2AR, experimentally confirmed binding molecules were obtained, with per-target hit rates ranging from 12.1% to 100%, and the best binding molecules all achieved nanomolar affinity. The report also shows that MMFold achieved a Top-1 high-quality success rate of 39.0% in 172 interface evaluations of antibody-antigen complex structure prediction in FoldBench, compared with 19.8% for AlphaFold 3.
MoleculeMind has released a technical report on its AI de novo protein design platform MMDesign, covering 19 design projects across 18 targets and two modalities—nanobodies and macrocyclic peptides—of which 18 yielded bindable molecules, for a project success rate of 94.7%; among 453 tested candidates, 139 were confirmed to bind, for a candidate hit rate of 30.7%. For all six GPCR targets CCR7, CCR8, EP2, GPR68, NK3R, and A2AR, experimentally confirmed binding molecules were obtained, with per-t
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