MoleculeMind MMDesign Technical Report: 18 of 19 Projects Successful, All 6 GPCR Targets Hit
MoleculeMind has released a technical report on its AI protein de novo design platform MMDesign, covering 19 projects across 18 targets and two modalities—nanobodies and macrocyclic peptides—with 18 yielding experimentally confirmed binders, a project success rate of 94.7%; of 453 tested candidates, 139 were hits, a candidate hit rate of 30.7%. All six GPCR targets succeeded, with best affinities reaching the nanomolar level: GPR68 achieved a best KD as low as 12.1 nM, and all 30 candidates for NK3R were confirmed to bind. The report also shows that when redesigning against 6 targets that already had binders, 5 achieved improvements, and it presents results for the structure prediction model MMFold on the FoldBench antibody–antigen interface benchmark.
MoleculeMind has released a technical report on its AI protein de novo design platform MMDesign, covering 19 projects across 18 targets and two modalities—nanobodies and macrocyclic peptides—with 18 yielding experimentally confirmed binders, a project success rate of 94.7%; of 453 tested candidates, 139 were hits, a candidate hit rate of 30.7%. All six GPCR targets succeeded, with best affinities reaching the nanomolar level: GPR68 achieved a best KD as low as 12.1 nM, and all 30 candidates for
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