Greg Brockman shares new lead from GPT-Rosalind in drug discovery
Greg Brockman shared OpenAI's progress on GPT-Rosalind: the model has surfaced a new lead in drug discovery, namely whether restoring cholesterol transport could protect neurons from degeneration. OpenAI says DCTN1 is a gene associated with Perry syndrome, and that disrupting it in mouse brain data increased the expression of genes involved in cholesterol synthesis; on this basis, GPT-Rosalind hypothesized that cholesterol may not be reaching where neurons need it. In collaboration with PerturbAI and Scripps Research, thousands of GPT-Rosalind agents worked in parallel, linking gene expression results from millions of mouse brain cells with scientific literature within 32 minutes, and OpenAI says it is expanding this collaboration to find new drug targets.
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OpenAI discloses that GPT-Rosalind linked gene expression in millions of mouse brain cells with scientific literature within 32 minutes, yielding a verifiable hypothesis about a cholesterol transport mechanism.
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View original postGPT-Rosalind surfaced a new lead for drug discovery: could restoring cholesterol transport protect neurons from degeneration? DCTN1 is a gene linked to Perry syndrome, a rare neurodegenerative disorder. In mouse-brain data, disrupting it increased expression of genes involved in making cholesterol. GPT-Rosalind suggested a possible explanation: cholesterol may not be reaching where neurons need it. That gives scientists a specific mechanism to test and, if confirmed, a direction for developing new treatments for neurodegenerative disorders. With @perturbai_tx and @scrippsresearch, a team of thousands of GPT-Rosalind agents worked in parallel, connecting gene-expression results from millions of mouse brain cells with scientific literature in just 32 minutes. We’re now expanding this collaboration to identify new drug targets. https://t.co/oHdF3ELsMj
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GPT-Rosalind surfaced a new lead for drug discovery: could restoring cholesterol transport protect neurons from degeneration? DCTN1 is a gene linked to Perry syndrome, a rare neurodegenerative disorder. In mouse-brain data, disrupting it increased expression of genes involved in making cholesterol. GPT-Rosalind suggested a possible explanation: cholesterol may not be reaching where neurons need it. That gives scientists a specific mechanism to test and, if confirmed, a direction for developing new treatments for neurodegenerative disorders. With @perturbai_tx and @scrippsresearch, a team of thousands of GPT-Rosalind agents worked in parallel, connecting gene-expression results from millions of mouse brain cells with scientific literature in just 32 minutes. We’re now expanding this collaboration to identify new drug targets. https://t.co/oHdF3ELsMj
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Rosalind for new drug discovery ideas: