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Databricks and NVIDIA plan to integrate NVIDIA BioNeMo's open-source protein design model RFD4-Proteina into Databricks' Genesis Workbench. According to a Databricks blog post dated October 21, 2026, the model will run on the generally available AI Runtime serverless NVIDIA GPU compute. RFD4-Proteina can simultaneously generate protein sequences and all-atom structures, and supports optional reward-guided search that steers candidate designs toward target properties such as thermostability and binding affinity. Genesis Workbench includes two built-in RFD4-Proteina workflows, Antibody Design and Vaccine Design, and can be extended through Genie Code and NVIDIA BioNeMo Agent Toolkit skills. No further progress has been disclosed at this time.
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Deploying the RFD4-Proteina model on DatabricksDevelopments
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Databricks and NVIDIA bring RFD4-Proteina to Genesis Workbench
Source:Databricks Blog
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Oct 21
Databricks BlogFirst-party
Deploying the RFD4-Proteina model on Databricks
NVIDIA and Databricks plan to integrate NVIDIA BioNeMo's open-source protein design model RFD4-Proteina into Databricks' Genesis Workbench, running on the now generally available AI Runtime serverless NVIDIA GPU compute. The model can simultaneously generate protein sequences and all-atom structures, and supports optional reward-guided search to steer candidate designs toward target properties such as thermostability and binding affinity. Genesis Workbench includes two built-in RFD4-Proteina workflows, Antibody Design and Vaccine Design, and can be extended through Genie Code and NVIDIA BioNeMo Agent Toolkit skills.