Claude 设计抗蝎毒神经毒素蛋白结合体,211 个设计中 17 个达标
Anthropic 让内部研究模型在 Claude Science 中自主设计针对蝎毒神经毒素的 minibinder,64 小时内生成 318,484 个设计并选出 180 个,加上团队补充的 31 个共 211 个交由 Adaptyv Bio 和 Twist Bioscience 实验测试,其中 17 个达到结合体标准。这 17 个均针对单一毒素,多毒素设计无一达标;最强候选 Cn2-B1 和 Cn2-B2 与 Cn2 的结合亲和力在个位数纳摩尔级,竞争实验显示它们与已知中和抗体 LR 结合同一表位附近。研究尚未在细胞或活体动物中验证中和效果,Anthropic 不称其为抗毒血清,并公开全部 211 个设计及数据。
discovery. This is especially true for neglected diseases such as animal envenomings, which have been largely starved of innovation due to low commercial incentives. Being able to agentically tackle the uniquely broad target space across animal toxins provides a significant speed-up in discovery, and brings realistic therapeutic solutions much closer. Timothy P. Jenkins , Associate Professor, Technical University of Denmark. Claude ran the design campaign with considerable autonomy Our initial p
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