Claude Science 自主设计蛋白结合体，靶向蝎毒神经毒素
Claude Science tackles deadly scorpion stings by designing protein binders from scratch
Anthropic 的 Claude 在 Claude Science 研究环境中基本自主设计了靶向蝎毒神经毒素的蛋白结合体，这类毒素每年致死超过 3250 人。Claude 针对 4 种蝎子的 5 种毒素生成 318484 个设计，在初始提示后自主工作 24 小时，随后由研究团队追加指令引导。Claude 选出 180 个候选、团队补充 31 个，实验室测试的 211 个设计中有 17 个符合结合体标准，其中最强的两个与墨西哥蝎毒素 Cn2 紧密结合，但尚未测试其是否真能作为抗毒血清。
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AI 评分 74
Claude 在 24 小时内自主生成 31 万余个蛋白结合体设计，实验室测试 211 个中有 17 个达标，可作为 AI 自主科研的量化参考。
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Anthropic's Claude largely autonomously designed protein binders targeting scorpion neurotoxins, which kill more than 3,250 people every year. These small protein molecules are shaped to latch onto a specific target molecule. Claude generated 318,484 designs for such protein binders targeting five toxins from four scorpion species. After an initial prompt, Claude worked on its own for 24 hours. The research team then steered the work with additional instructions.
Claude picked 180 candidates, and the team added 31 more. Of the 211 designs tested in the lab, 17 met the criteria for a binder. The two strongest bound extremely tightly to Cn2, a toxin from the Mexican scorpion. Lab tests suggest they dock at or near the same site as an antibody known to neutralize Cn2 in mice. Whether they actually work as an antivenom hasn't been tested yet.
External experts Susana Vázquez Torres and Timothy P. Jenkins called the work a promising first step. Two independent labs confirmed the results. Claude worked inside Claude Science , Anthropic's AI environment for researchers. In an earlier study , Claude had already designed mini-binders against 14 of 15 target proteins, with hit rates of 22 to 35 percent compared to the typical 10 to 15 percent.