Claude 在 Claude Science 中自主设计出 17 个结合蝎毒神经毒素的分子
Claude did the protein scientist’s job and came back with 17 molecules that grip scorpion neurotoxins.
Claude 在 Anthropic 的 Claude Science 环境中以智能体身份自主完成整轮蛋白质设计：自行选定蝎毒神经毒素的攻击位点、驱动 12 个蛋白质设计程序、设定评分阈值，并从生成的 318,484 个分子中挑出 180 个送去做物理合成；在 Adaptyv Bio 和 Twist Bioscience 测试的 211 个设计中，有 17 个成功结合目标毒素。提出需求的是没有实验室和蛋白质专业背景的金融公司 Citrini Research。Anthropic 未将其称为抗蛇毒血清，因为能支撑这一说法的测试尚未进行。
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这条内容给出了智能体自主完成蛋白质设计的关键数字与验证结果，也点明了尚未做抗蛇毒血清验证的边界。
主题
查看原帖科学博客新文章：设计针对蝎毒神经毒素的蛋白质结合剂。 蝎子每年蜇伤约120万人，而抗毒血清往往价格昂贵或供应短缺。Claude 已朝着寻找新疗法迈出了早期一步。 https://t.co/l6LgdEqM7I
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New on our Science Blog: designing protein binders against scorpion neurotoxins. Scorpions sting about 1.2m people every year, and antivenoms are often costly or in short supply. Claude has made an early step toward finding new treatments. https://t.co/l6LgdEqM7I
正文
Claude did the protein scientist’s job and came back with 17 molecules that grip scorpion neurotoxins.
Claude, running as an agent inside Anthropic’s Claude Science setup, ran the whole protein-design campaign itself:
it picked which patch of each scorpion toxin to attack, drove 12 protein-design programs, set its own scoring cutoffs, and chose 180 molecules out of the 318,484 it generated for physical synthesis, and 17 of the 211 designs tested bound their toxin at Adaptyv Bio and Twist Bioscience.
Citrini Research, a finance firm with no lab and no protein expertise, asked for this work, and Claude designed proteins that two labs confirmed latch onto scorpion venom toxins.
Scorpion stings kill more than 3,250 people a year, so the prize is real, if this method works. However, Anthropic is not calling this an antivenom, because the test that would justify the word has not been run yet.