中国团队与 Hugging Face 将自然语言提示引入蛋白质和 DNA 设计
Vibe genes? Natural(ish) language comes to protein, genome design software
中国多家机构的研究人员合作开发出一款工具，可接收自然语言提示并生成具有指定功能的蛋白质，但按能否得到可用蛋白质衡量，成功率并不高。Hugging Face 另发公告称正在托管一款在 DNA 层面做类似工作的工具。原文指出，这类工具相当于把 vibe coding 带到蛋白质设计，前提是使用者有实验室可以筛掉大量失败设计。
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中国团队与 Hugging Face 分别把自然语言提示引入蛋白质和 DNA 设计，读者可了解这类工具的可用边界。
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Protein design tools may be getting increasingly sophisticated, but you still need a sophisticated understanding of protein structure for them to work. This can include knowing enzyme mechanisms down to the positions of specific amino acids, as well as the water molecules that also occupy the area where catalysis takes place. Once you specify these, the tools can build the rest of a protein around this target.
A large collaboration of researchers based in China, however, decided to bring protein design to the masses, making a tool that can take natural language prompts and use them to produce proteins with the function you specify. If your measure for success is a working protein, then the success rate may not be great. But they still manage to get the job done. And, in a separate announcement, Hugging Face shared that it's now hosting a tool that does similar things on the DNA level.
The equivalent of vibe coding may have come to protein design—at least if you have access to a lab where you can sort the good designs from the dozens of failed ones.
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